Chemical Senses Seminar Fall 2016
We will meet from 330 pm to 430pm every Monday in King 3009. All are welcome.
We explore the role of taste in the regulation of food intake through a conceptual framework of feeding established over the last 70 years, via papers which ask the following sorts of questions:
- Is taste necessary for feeding?
- Is taste sufficient for feeding?
- What if taste is eliminated?
- Is ingestion a function of taste? (rate, amount, meal size vs. meal frequency)
- Is taste preference a function of metabolic state?
- Do postingestive/metabolic signals modulate taste-driven reflexes?
- Can taste-driven ingestion be dissociated from postingestive/metabolic consequences?
- How do we determine the characteristics of a food which drives intake?
- how is taste defined as "rewarding"? What are substrates for food-driven reward?
Davis, J.D. and Breslin, P.A.S. A behavioral analysis of the ingestion of glucose, maltose and maltooligosaccharide by rats. Physiol Behav
69 (2000) 477–485.
Davis JD, Smith GP, Kung TM. Cholecystokinin changes the duration but not the rate of licking in vagotomized rats. Behav Neurosci 1995 Oct;109(5):991-6.
Epstein, A. N. and Teitelbaum, P. Regulation of food intake in the absence of taste, smell, and other oropharyngeal sensations. J Comp Physiol Psychol 55 (1962) 753-759.
Gul, S.S. et al. Inhibition of the gut enzyme intestinal alkaline phosphatase may explain how aspartame promotes glucose intolerance and obesity in mice. Appl. Physiol. Nutr. Metab. (2016)
Hajnal, A. and Norgren, R. Accumbens dopamine mechanisms in sucrose intake. Brain Research 904 (2001) 76–84
Hajnal, A., Smith, G.P. and Norgen, R. Oral sucrose stimulation increases accumbens dopamine in the rat. Amer J Physiol 286 (2004) R31–R37
Holman, G. L. Intragastric reinforcement effect. J Comp Physiol Psychol 69 (1969) 432-441.
Houpt, K.A. Motivation for cribbing by horses. Animal Welfare 21 (2012) 1-7.
Kalianan, K. et al. Intestinal alkaline phosphatase prevents metabolic syndrome in mice. PNAS 110 (2013) 7003 - 7008.
Lee, R.J. and Cohen, N.A. ole of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Curr Opin Allergy Clin Immunol 15 (2015) 14 – 20.
Lee, R.J. et al. Bitter and sweet taste receptors regulate human upper respiratory innate immunity. J Clin Invest 124 (2014) 1393 - 1405.
Marinella, M.A. Nocturnal pagophagia complicating gastric bypass. Mayo Clin Proc. 83(2008)961-962.
Panaro, B.L and Cone, R. D. Melanocortin-4 receptor mutations paradoxically reduce preference for palatable foods. PNAS 17 (2013) 7050–7055.
Rothwell, N.J. and Stock M.J. Regulation of energy balance in two models of reversible obesity in the rat. J Comp Physiol Psychol 93 (1979) 1024 - 1034.
Sclafani, A. and Ackroyd, K. Glucose- and fructose-conditioned flavor preferences in rats: taste versus postingestive conditioning. Physiol Behav 56 (1994) 399-405
Sclafani, A. and Springer, D. Dietary obesity in adult rats: similarities to hypothalamic and human obesity syndromes. Physiol Behav 17 (1976) 461-471.
van der Klaauw, A.A. et al. Divergent effects of central melanocortin signalling on fat and sucrose preference in humans. Nature Commun.
Wise, R.A. Dopamine and food reward: back to the elements. Am J Physiol 286 (2004) R13
Woods, S.C. and Weisinger, R.S. Pagophagia in the albino rat. Science 169 (1970) 1334-1336.
© 2014 T.A. Houpt. Last updated 2019-12-02.